CCT and IOP in Children Undergoing Congenital Cataract Surgery
The authors of this Brazilian study investigated changes in central corneal thickness (CCT) and intraocular pressure (IOP) in children following congenital cataract surgery, as well as risk factors associated with these changes.
They prospectively recruited 37 eyes of 26 children with congenital cataract undergoing surgery and performed IOP and CCT measurements before the surgery and six, 12, 18, 24 and 36 months after the procedure.
Among the 37 eyes, 15 became aphakic and 22 pseudophakic, the authors reported. They also found that mean CCT significantly increased from 556.24 ± 44.19 to 585.07 ± 56.45 µm (p=0.003) after three years, whereas mean IOP significantly increased from 12.05 ± 2.3 to 13.89 ± 2.96 mmHg (p=0.037). The authors also reported that aphakic eyes underwent surgery at an early age (15.16 ± 32.02 months) compared with pseudophakic eyes (71.48 ± 53.14 months) (p<0.001). After three years, they found that mean CCT change in aphakic eyes (56.10 ± 46.97 µm) was significantly higher than in pseudophakic eyes (12.71 ± 38.41 µm) (p=0.015). Age at the time of surgery was inversely correlated to CCT change (r=–0.34, p=0.04), but not to IOP change (r=–0.18, p=0.27). When surgery was performed between zero and one year of age, mean CCT change at three years was 70.11 ± 42.3 µm, compared with 6.27 ± 28.09, –17.0
± 8.04 and 48.33 ± 34.99 µm when surgeries were performed at 1–5, 5–10 and >10 years old, respectively (p<0.001). IOP change was not correlated to CCT change (r=0.31, p=0.06).
In conclusion, CCT increases in eyes undergoing congenital cataract surgery, especially when the surgery is performed at an early age.