Correlation Between Sleep Apnea and Risk of RVO
Researchers aimed to explore the relationship of sleep apnea and the subsequent development of retinal vein occlusion (RVO). They conducted a retrospective nonrandomized, matched-control cohort study using the Taiwan National Health Insurance Research Database and found that sleep apnea may be an independent risk factor for RVO.
From 1997 through 2007, they identified newly diagnosed sleep apnea cases in the database and selected a control group without sleep apnea, matched for age, gender and comorbidities, for comparison. Additionally, they followed the 2 cohorts and observed and the occurrence of RVO.
The researchers noted that of the 35,634 sampled patients (5,965 sleep apnea patients vs 29,669 controls), 52 (0.15%) experienced RVO during a mean follow-up period of 3.72 years, including 13 (0.22%, all branch RVO) from the sleep apnea cohort and 39 (0.13%, 39 branch RVO and 10 central RVO) from the control group. Kaplan-Meier analysis revealed the tendency of sleep apnea patients toward RVO development (p = .048, log-rank test). Furthermore, patients with sleep apnea experienced a 1.94-fold increase (95% confidence interval, 1.03 to 3.65; p = .041) in incident RVO, which was independent of age, gender and comorbidities.